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pentobarbital will reduce the extent or effect of phenytoin by influencing hepatic enzyme CYP2C9/10 metabolism. Use Caution/Watch.pentobarbital will decrease the level or impact of clozapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will lessen the extent or result of artemether/lumefantrine